Publications

Stanley SE, Chen JJ, Podlevsky JD, Alder JK, Hansel NN, Mathias RA, Qi X, Rafaels NM, Wise RA, Silverman EK, Barnes KC, Armanios M. Telomerase mutations in smokers with severe emphysema. J Clin Invest. 2015 Feb;125(2):563-70. doi: 10.1172/JCI78554. Epub 2014 Dec 22. PubMed PMID: 25562321.

Alder JK, Stanley SE, Wagner CL, Hamilton M, Hanumanthu VS, Armanios M. Exome sequencing identifies mutant TINF2 in a family with pulmonary fibrosis. Chest. 2014 Dec 24. doi: 10.1378/Chest.14-1947. [Epub ahead of print] PubMed PMID: 25539146. 
 
Alder, J. K., Parry, E.M., Yegnasubramanian, S., Wagner, C.L., Lieblich, L.M., Auerbach, R., Auerbach, .AD., Wheelan, S.J., Armanios, M. Telomere phenotypes in females with heterozygous mutations in the dyskeratosis congenita 1 (DKC1) gene. Hum Mutat, 2013. 34(11):1481-5. PMCID: PMC3926107

Alder, J. K., Guo, N., Kembou, F., Perry, E.M., Anderson, C.J., Gorgy, A.I., Walsh, M.F., Tuder, R.M., Armanios, M. Telomere length is a determinant of Emphysema Susceptibility. Am J Respir Crit Care Med. 2011. 184: 904-912.

Parry, E. M., Alder, J. K., Lee, S. S., Phillips, J. A., 3rd, Loyd, J. E., Duggal, P. and Armanios, M., Decreased dyskerin levels as a mechanism of telomere shortening in X-linked dyskeratosis congenita. J Med Genet, 2011. 48(5): p. 327-33. PMCID: PMC3088476

Parry, E. M., Alder, J. K., Qi, X., Chen, J. J. and Armanios, M., Syndrome complex of bone marrow failure and pulmonary fibrosis predicts germline defects in telomerase. Blood, 2011. 117(21): p. 5607-11. PMCID: PMC3110022

Alder, J. K., Cogan, J. D., Brown, A. F., Anderson, C. J., Lawson, W. E., Lansdorp, P. M., Phillips, J. A., 3rd, Loyd, J. E., Chen, J. J. and Armanios, M., Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis. PLoS Genet, 2011. 7(3): p. e1001352. PMCID: PMC3069110

Healey, M. A., Deaton, S. L., Alder, J. K., Winnepenninckx, V., Casero, R. A., Jr. and Herman, J. G., Id1 overexpression is independent of repression and epigenetic silencing of tumor suppressor genes in melanoma. Epigenetics, 2010. 5(5): p. 410-21.

Lebson, L., Gocke, A., Rosenzweig, J., Alder, J. K., Civin, C., Calabresi, P. A. and Whartenby, K. A., Cutting edge: The transcription factor Kruppel-like factor 4 regulates the differentiation of Th17 cells independently of RORgammat. J Immunol, 2010. 185(12): p. 7161-4. PMCID: PMC3071015

Armanios, M., Alder, J. K., Parry, E. M., Karim, B., Strong, M. A. and Greider, C. W., Short telomeres are sufficient to cause the degenerative defects associated with aging. Am J Hum Genet, 2009. 85(6): p. 823-32. PMCID: PMC2790562

Alder, J. K., Georgantas, R. W., 3rd, Hildreth, R. L., Kaplan, I. M., Morisot, S., Yu, X., McDevitt, M. and Civin, C. I., Kruppel-like factor 4 is essential for inflammatory monocyte differentiation in vivo. J Immunol, 2008. 180(8): p. 5645-52. PMCID: PMC3074963

Alder, J. K., Chen, J. J., Lancaster, L., Danoff, S., Su, S. C., Cogan, J. D., Vulto, I., Xie, M., Qi, X., Tuder, R. M., Phillips, J. A., 3rd, Lansdorp, P. M., Loyd, J. E. and Armanios, M. Y., Short telomeres are a risk factor for idiopathic pulmonary fibrosis. Proc Natl Acad Sci U S A, 2008. 105(35): p. 13051-6. PMCID: PMC2529100

Georgantas, R. W., 3rd, Hildreth, R., Morisot, S., Alder, J. K., Liu, C. G., Heimfeld, S., Calin, G. A., Croce, C. M. and Civin, C. I., CD34+ hematopoietic stem-progenitor cell microRNA expression and function: a circuit diagram of differentiation control. Proc Natl Acad Sci U S A, 2007. 104(8): p. 2750-5. PMCID: PMC1796783

Armanios, M. Y., Chen, J. J., Cogan, J. D., Alder, J. K., Ingersoll, R. G., Markin, C., Lawson, W. E., Xie, M., Vulto, I., Phillips, J. A., 3rd, Lansdorp, P. M., Greider, C. W. and Loyd, J. E., Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med, 2007. 356(13): p. 1317-26

Yu, X., Alder, J. K., Chun, J. H., Friedman, A. D., Heimfeld, S., Cheng, L. and Civin, C. I., HES1 inhibits cycling of hematopoietic progenitor cells via DNA binding. Stem Cells, 2006. 24(4): p. 876-88

De Las Penas, A., Pan, S. J., Castano, I., Alder, J. K., Cregg, R. and Cormack, B. P., Virulence-related surface glycoproteins in the yeast pathogen Candida glabrata are encoded in subtelomeric clusters and subject to RAP1- and SIR-dependent transcriptional silencing. Genes Dev, 2003. 17(18): p. 2245-58. PMCID: PMC196462

Flanigan, K. M., von Niederhausern, A., Dunn, D. M., Alder, J. K., Mendell, J. R. and Weiss, R. B., Rapid direct sequence analysis of the dystrophin gene. Am J Hum Genet, 2003. 72(4): p. 931-9. PMCID: PMC1180355

Dunn, D. M., Ishigami, T., Pankow, J., von Niederhausern, A., Alder, J. K., Hunt, S. C., Leppert, M. F., Lalouel, J. M. and Weiss, R. B., Common variant of human NEDD4L activates a cryptic splice site to form a frameshifted transcript. J Hum Genet, 2002. 47(12): p. 665-76